Articles

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56 articles
41
Research Article

Mucinous carcinoma upregulates targets ‎of small ‎molecule ‎inhibitors of cancers: implications ‎for ‎targeting oncogenic mucins in the colorectal cancer microenvironment

Henry Ebili*, Adesoji Ebenezer Adetona, Patrick Akintunde Akintola, Uchenna Simon Ezenkwa, Kazeem Adeyinka Adegboyejo, Ayotunde O. Ale, Yusuf Abdullahi

Background: Mucinous colorectal carcinoma (CRC) is a distinct histological subtype ‎associated with abundant extracellular mucin production, adverse clinicopathological features, ‎chemoresistance, and poor prognosis. However, the tumour microenvironment (TME) signalling ‎characteristics of mucinous CRC and its potential vulnerabilities to anti-mucin small molecule ‎inhibitors (SMIs) remain incompl...

Aug, 2026 pp. 219-241 9 views 7 downloads
42
Research Article DOI: 10.67579/njo.2025.qe8i4g5m

EFFECTIVENESS OF TRAINING WORKSHOP ON THE ATTITUDE OF HEALTHCARE PROVIDERS TOWARDS BREAKING BAD NEWS TO CANCER PATIENTS: A MULTI- INSTITUTIONAL STUDY

Samuel A. Otene*, Shehu Salihu Umar, Ali Abba Tijjani, DA Bojude D, Foluke O. Sarimiye, Sani B. Abubakar, Vitalis C. Okwor, Emmanuel Aimebelomo Ikhile, Auwal G. Suleiman, Suleiman K. Hamidu, Vivian C. Nwordu, Nwamaka Lasebikan, Musa Ali-Gombe, Usman M. Aliyu

Background: Breaking bad news (BBN) is a critical aspect of oncology care. Unfortunately, many healthcare providers (HCPs) in Nigeria lack formal training in this skill.Objective: This study evaluated the effectiveness of a training workshop on HCPs’ attitudes towards BBN to cancer patients across multiple institutions in Nigeria.Methods: A quasi-experimental study was conducted across six federal...

Jul, 2025 pp. 220-233 236 views 133 downloads
43
Research Article DOI: 10.67579/njo.2025.xstu1r2d

ASSESSMENT OF COMPLIANCE TO CHEMOTHERAPY AMONGST BREAST CANCER PATIENTS IN A RADIOTHERAPY FACILITY: A PROSPECTIVE STUDY

Gaddafi Yusuf*, Sunday A. Adewuyi, Ismail H. Zubairu

Background: Breast cancer is a leading cause of cancer-related deaths worldwide, particularly in Sub-Saharan Africa, where late-stage presentation and poor compliance with therapy are prevalent.Objective: To assess the level of compliance with chemotherapy among breast cancer patients and identify factors associated with compliance in a tertiary hospital in Northern Nigeria.Methods: A prospective ...

Jul, 2025 pp. 234-248 235 views 186 downloads
44
Research Article DOI: 10.67579/njo.2025.awhnvbsl

EFFECT OF PSYCHOEDUCATIONAL INTERVENTION ON ANXIETY AMONG BREAST CANCER PATIENTS IN AHMADU BELLO UNIVERSITY TEACHING HOSPITAL ZARIA

Aminu Bello Liman*, Munir Sani, Shehu Salihu Umar, Ismail H. Zubairu, Audu I. Aveka, Tajudeen A. Olasinde

Background: Breast cancer (BC) is a disease of global public health concern whose incidence is rising, leading to significant morbidity and mortality. Psychological burden associated with BC diagnosis and treatment has negative consequences on the patients in addition to physical symptoms. Many psychosocial interventions have been developed and evaluated to reduce psychological disorders such as a...

Jul, 2025 pp. 249-265 353 views 152 downloads
45
Research Article DOI: 10.67579/njo.2025.zg6ha74d

SEX DISPARITY IN CANCER OCCURRENCE AND TREATMENT AMONG CANCER PATIENTS: A 2-YEAR RETROSPECTIVE STUDY OF THE ONCOLOGY UNIT, FEDERAL TEACHING HOSPITAL, GOMBE

Khadijat A. Bobbo*, Amina U. Babuga, Zubairu S. Rayyanu, Abdulrahman Adamu, Danladi A. Bojude

Background: Sexual disparity in cancer prevalence and treatment approaches is a crucial factor in achieving effective cancer treatment and management globally. This study aimed to investigate gender-specific patterns of cancer types and treatments among patients in Nigeria.Objective: To determine the prevalence of different cancer types and associated treatment modalities, highlighting any sexual ...

Jul, 2025 pp. 266-279 239 views 168 downloads
46
Research Article DOI: 10.67579/njo.2025.c5fsm2w9

PATTERN OF METASTATIC BREAST CANCER IN NIGERIA: A RETROSPECTIVE REVIEW OF CASES FROM NATIONAL HOSPITAL, ABUJA

Fatima Inno Uba*, Simeon C. Aruah, Festus Igbinoba, Rasaaq A. Oyesegun

Background: Metastatic Breast Cancer is a common presentation among breast cancer patients in Nigeria. There has been a slight decline in breast cancer mortality, which can be attributed both to the success of early detection programs and advances in treatment.Objective: To determine the pattern, sites, and outcomes of metastatic breast cancer among patients treated at the National Hospital, Abuja...

Jul, 2025 pp. 280-288 230 views 160 downloads
47
Research Article DOI: 10.67579/njo.2025.z2hnreiu

EFFECTS OF ANDROGEN DEPRIVATION THERAPY ON FASTING BLOOD GLUCOSE IN PROSTATE CANCER PATIENTS AT A TEACHING HOSPITAL IN SOUTHWESTERN NIGERIA - A PILOT STUDY

Daluchukwu J. Obi*, Chiamaka Ehiedu, Abbas A Abdus-Salam, Atara I Ntekim, Augustine Takure, Ifeanyichukwu Nwanji, Olumide Farinre, Adeniyi Adenipekun

Background: Prostate cancer is the most common cancer and the leading cause of cancer death in Nigerian men. There are many modalities of treatment of prostate cancer, among them is hormonal treatment with the use of androgen-deprivation therapy (ADT), and this has been reported to have effects on the blood glucose level, causing hyperglycaemia.Objective: To determine the effects of three-month ad...

Jul, 2025 pp. 289-299 261 views 139 downloads
48
Research Article DOI: 10.67579/njo.2025.bfjzda3v

EFFECTS OF BRACHYTHERAPY BOOST ON PROSTATE CANCER TREATED WITH EXTERNAL BEAM RADIOTHERAPY: A PILOT STUDY

Abbas A. Abdus-salam*, Olabisi T. Ojo, Chiamaka Ehiedu, Maryam A. Bashir, Atara I Ntekim, Adewumi O. Alabi, Sharif A. Folorunso, Jimoh mutiu alani, Foluke O. Sarimiye, Adeniyi Adenipekun

Background: Prostate cancer is the leading cause of cancer amongst men in Nigeria. External beam radiotherapy (EBRT) and high-dose rate brachytherapy (HDR-BT) play a significant role in the management of localised prostate cancer.Objective: This study compared the treatment outcome of the management of intermediate and high-risk localised prostate cancer patients using EBRT alone and EBRT + BT.Met...

Jul, 2025 pp. 300-312 279 views 188 downloads
49
Research Article DOI: 10.67579/njo.2025.xr23ody7

A PROGRESSIVE EMBRYONAL RHABDOMYOSARCOMA OF THE UTERINE CERVIX WITH RIGHT BREAST LUMP IN A 43-YEAR-OLD ADULT: A CASE REPORT

Amina I Dansani*, Tajudeen A. Olasinde, Olabisi T. Ojo, Aisha Mustapha, Shehu Abdullahi, Shehu Salihu Umar

Introduction: Embryonal Rhabdomyosarcoma is an uncommon type of sarcoma often seen in pediatric and adolescent patients, with the botryoid subtype being the most common. The incidence of this disease in adult females is 0.4% to 1% with the affected age group being patients in the third to fourth decade of life. It is rare in patients above 40 years in Nigeria.Case Presentation: We describe the cas...

Jul, 2025 pp. 313-320 284 views 169 downloads
50
Research Article DOI: 10.67579/njo.2025.jsg8ad20

PRIMARY FEMUR NEUROBLASTOMA IN A 16-YEAR-OLD: A CASE REPORT

Adewumi O. Alabi*, Bright A. Igbinoba, Olusola K. Idowu, Kolawole O. Aramide, Nnamdi Orah, Mohammed Y.M. Habeebu, Opeyemi I. Olusunmade, Emmanuel E. Ojiebun

The incidence of neuroblastomas in individuals aged 10 and above is less than 10%. It is also associated with poor prognosis in older children and adults. This is a case report of a 16-year-old lady with pain and swelling in the left knee. The definitive diagnosis was neuroblastoma in the left distal femur after immunohistochemistry. The patient underwent surgery and chemotherapy. Extremity neurob...

Jul, 2025 pp. 321-327 265 views 153 downloads