Research Article

SEX DISPARITY IN CANCER OCCURRENCE AND TREATMENT AMONG CANCER PATIENTS: A 2-YEAR RETROSPECTIVE STUDY OF THE ONCOLOGY UNIT, FEDERAL TEACHING HOSPITAL, GOMBE

1 Department of Human Anatomy, Faculty of Medicine and Allied Sciences, College of Medical Sciences, Gombe State University, Gombe State, Nigeria
2 Department of Human Anatomy, Faculty of Medicine and Allied Sciences, College of Medical Sciences, Gombe State University, Gombe State, Nigeria.
3 Department of Oncology, Faculty of Medicine, Gombe State University/ Federal Teaching Hospital 760253 GSU, Gombe State-Nigeria.
* Corresponding author: khadijatabobbo@ngjoncology.com
Published: Jul, 2025
Pages: 266-279
Views: 239
Downloads: 168

Abstract

Background: Sexual disparity in cancer prevalence and treatment approaches is a crucial factor in achieving effective cancer treatment and management globally. This study aimed to investigate gender-specific patterns of cancer types and treatments among patients in Nigeria.


Objective: To determine the prevalence of different cancer types and associated treatment modalities, highlighting any sexual dimorphism among patients attending the Oncology Unit of the Federal Teaching Hospital, Gombe, Nigeria, between 2022 and 2024.


Methods: This was a two-year (2022-2024) retrospective study. Data on patient demographics, cancer types, and treatment modalities were systematically collected from oncology ward records at the Federal Teaching Hospital, Gombe.


Results: A higher overall prevalence of cancer was observed in females. Gynecological cancers (cervical and ovarian) and breast cancer are the most common among females, while prostate and gastrointestinal (GIT) cancers are predominant in males. Cancers are treated either as a standalone therapy or in combination. No significant gender difference was found in the use of standalone chemotherapy. However, combination therapy involving chemotherapy and surgery was more common in male patients, while other multi-modal treatments incorporating radiotherapy, surgery, and brachytherapy were less frequent across both genders.


Conclusion: Significant gender disparities in cancer types and treatment patterns exist among patients at the Oncology Unit of the Federal Teaching Hospital, Gombe. Females showed higher overall cancer incidence, primarily with breast and gynecological cancers, while males exhibited higher rates of prostate and GIT cancers. Gender differences were observed in treatment modalities, likely influenced by the anatomical locations of organs, such as the deep ovary versus the more superficial prostate.


References

  1. Kroon J, Mahmoodzadeh S, Helsen C. Editorial: Sexual dimorphism in biomedical research and its therapeutic implications. Front Endocrinol (Lausanne) 2022;13:1009712.
  2. Kleisner K, Tureček P, Roberts SC, Havlíček J, Valentova JV, Akoko RM, et al. How and why patterns of sexual dimorphism in human faces vary across the world. Sci Rep 2021;11(1):5978.
  3. Gay L, Melenotte C, Lakbar I, Mezouar S, Devaux C, Raoult D, et al. Sexual Dimorphism and Gender in Infectious Diseases. Front Immunol 2021;12:698121.
  4. Otten D, Tibubos AN, Schomerus G, Brähler E, Binder H, Kruse J, et al. Similarities and Differences of Mental Health in Women and Men: A Systematic Review of Findings in Three Large German Cohorts. Front Public Health 2021;9:553071.
  5. Bechmann N, Barthel A, Schedl A, Herzig S, Varga Z, Gebhard C, et al. Sexual dimorphism in COVID-19: potential clinical and public health implications. Lancet Diabetes Endocrinol 2022;10(3):221–30.
  6. Ventura-Clapier R, Piquereau J, Garnier A, Mericskay M, Lemaire C, Crozatier B. Gender issues in cardiovascular diseases. Focus on energy metabolism. Biochim Biophys Acta Mol Basis Dis 2020;1866(6):165722.
  7. Mello-Gentil T, Souza-Mello V. Contributions of anatomy to forensic sex estimation: focus on head and neck bones. Forensic Sci Res 2022;7(1):11–23.
  8. Kapur M, Shah RA, Ferro A, Basyuni S, Brassett C, Santhanam V. Sexual dimorphism and geographical variance: their impact on the reliability of the antilingula as a landmark in human mandibular surgery. Br J Oral Maxillofac Surg 2021;59(8):898–904.
  9. Zucker I, Prendergast BJ. Sex differences in pharmacokinetics predict adverse drug reactions in women. Biol Sex Differ 2020;11(1):32.
  10. Cherubini A, Della Torre S, Pelusi S, Valenti L. Sexual dimorphism of metabolic dysfunction-associated steatotic liver disease. Trends Mol Med 2024;30(12):1126–36.
  11. Vera R, Juan-Vidal O, Safont-Aguilera MJ, de la Peña FA, Del Alba AG. Sex differences in the diagnosis, treatment and prognosis of cancer: the rationale for an individualised approach. Clin Transl Oncol 2023;25(7):2069–76.
  12. Zheng D, Trynda J, Williams C, Vold JA, Nguyen JH, Harnois DM, et al. Sexual dimorphism in the incidence of human cancers. BMC Cancer 2019;19(1):684.
  13. Fitzmaurice C, Abate D, Abbasi N, Abbastabar H, Abd-Allah F, Abdel-Rahman O, et al. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol 2019;5(12):1749–68.
  14. Cao W, Qin K, Li F, Chen W. Comparative study of cancer profiles between 2020 and 2022 using global cancer statistics (GLOBOCAN). J Natl Cancer Cent 2024;4(2):128–34.
  15. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2024;74(3):229–63.
  16. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68(6):394–424.
  17. Sharma R, Aashima, Nanda M, Fronterre C, Sewagudde P, Ssentongo AE, et al. Mapping Cancer in Africa: A Comprehensive and Comparable Characterization of 34 Cancer Types Using Estimates From GLOBOCAN 2020. Front Public Health 2022;10:839835.
  18. National Institute for Cancer Research and Treatment (NICRAT). National Institute for Cancer Research and Treatment [Internet]. Abuja, Nigeria: National Institute for Cancer Research and Treatment, as it's the publishing body; 2025. Available from: [https://www.nicrat.gov.ng](https://www.nicrat.gov.ng)
  19. Chidebe RCW, Leibel LL, Orjiakor TC, Shrestha A, Agha AA, Altinok Dindar D, et al. Promoting cancer prevention through World Cancer Day in Nigeria. Lancet Oncol 2023;24(4):319–22.
  20. Koch M, Szabó É, Varga C, Soós V, Prenek L, Porcsa L, et al. Retrospective study of cancer patients' predictive factors of care in a large, Hungarian tertiary care centre. BMJ Open 2023;13(5):e070320.
  21. Al-Shami K, Awadi S, Khamees A, Alsheikh AM, Al-Sharif S, Ala' Bereshy R, et al. Estrogens and the risk of breast cancer: A narrative review of literature. Heliyon 2023;9(9):e20224.
  22. Feng Z, Liao M, Zhang L. Sex differences in disease: sex chromosome and immunity. J Transl Med 2024;22(1):1150.
  23. Schafer JM, Xiao T, Kwon H, Collier K, Chang Y, Abdel-Hafiz H, et al. Sex-biased adaptive immune regulation in cancer development and therapy. iScience 2022;25(8):104717.
  24. Siegel RL, Miller KD, Goding Sauer A, Fedewa SA, Butterly LF, Anderson JC, et al. Colorectal cancer statistics, 2020. CA Cancer J Clin 2020;70(3):145–64.
  25. Jedy-Agba E, Curado MP, Ogunbiyi O, Oga E, Fabowale T, Igbinoba F, et al. Cancer incidence in Nigeria: a report from population-based cancer registries. Cancer Epidemiol 2012;36(5):e271-278.
  26. Ferlay J, Colombet M, Soerjomataram I, Parkin DM, Piñeros M, Znaor A, et al. Cancer statistics for the year 2020: An overview. Int J Cancer 2021;33588.
  27. Zhu B, Gu H, Mao Z, Beeraka NM, Zhao X, Anand MP, et al. Global burden of gynaecological cancers in 2022 and projections to 2050. J Glob Health 2024;14:04155.
  28. Katagum DA, Ezenkwa US, Achanya SE, Lawan AI, Suleiman DE, Kadaura MU, et al. Spectrum of gynecologic malignancies in Northeastern Nigeria. Front Oncol 2025;15:1420113.
  29. Okunade KS, John-Olabode S, Adejimi AA, Oshodi YA, Osunwusi B, Ugwu AO, et al. Predictors of Pap smear testing uptake among women in Lagos, Nigeria. Ecancermedicalscience 2022;16:1368.
  30. Arnold M, Abnet CC, Neale RE, Vignat J, Giovannucci EL, McGlynn KA, et al. Global Burden of 5 Major Types of Gastrointestinal Cancer. Gastroenterology 2020;159(1):335-349.e15.
  31. Lou L, Wang L, Zhang Y, Chen G, Lin L, Jin X, et al. Sex difference in incidence of gastric cancer: an international comparative study based on the Global Burden of Disease Study 2017. BMJ Open 2020;10(1):e033323.
  32. Gaeta A, Tagliabue M, D'Ecclesiis O, Ghiani L, Maugeri P, De Berardinis R, et al. Are sex and gender considered in head and neck cancer clinical studies? NPJ Precis Oncol 2023;7(1):84.
  33. Kinsey-Trotman S, Nguyen A, Edwards S, Swalling A, Dasari P, Walsh D, et al. Influence of tumour grade on disease survival in male breast cancer patients: a systematic review. Breast Cancer Res Treat 2024;208(1):1–8.
  34. Kim HI, Lim H, Moon A. Sex Differences in Cancer: Epidemiology, Genetics and Therapy. Biomol Ther (Seoul) 2018;26(4):335–42.
  35. Lopes-Ramos CM, Quackenbush J, DeMeo DL. Genome-Wide Sex and Gender Differences in Cancer. Front Oncol 2020;10:597788.
  36. Anand U, Dey A, Chandel AKS, Sanyal R, Mishra A, Pandey DK, et al. Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics. Genes Dis 2023;10(4):1367–401.
  37. Amjad MT, Chidharla A, Kasi A. Cancer Chemotherapy. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025.
  38. Burmeister CA, Khan SF, Schäfer G, Mbatani N, Adams T, Moodley J, et al. Cervical cancer therapies: Current challenges and future perspectives. Tumour Virus Res 2022;13:200238.
  39. Lazzari G, Benevento I, Montagna A, D'Andrea B, De Marco G, Castaldo G, et al. Breast Cancer Adjuvant Radiotherapy in Up-Front to Chemotherapy: Is There a Worthwhile Benefit? A Preliminary Report. Breast Cancer (Dove Med Press) 2024;16:359–67.
  40. Praça MSL, Sousa FTR de, Cândido EB, Lamaita RM, Wender MCO, Silva Filho AL. Beyond the diagnosis: gender disparities in the social and emotional impact of cancer. Rev Assoc Med Bras (1992) 2024;70(suppl 1):e2024S115.
  41. Jardim SR, de Souza LMP, de Souza HSP. The Rise of Gastrointestinal Cancers as a Global Phenomenon: Unhealthy Behavior or Progress? Int J Environ Res Public Health 2023;20(4).
  42. Cassell A, Yunusa B, Jalloh M, Mbodji MM, Diallo A, Ndoye M, et al. A Review of Localized Prostate Cancer: An African Perspective. World J Oncol 2019;10(4–5):162–8.
  43. Uttam AK, Yadav AK, Jalota S, Singh R, Malik S, Arya AK. A prospective randomized comparative study to evaluate the effect of palliative hypo-fractionated radiotherapy with concurrent chemotherapy versus hypo-fractionated radiotherapy alone in advanced and unresectable head and neck cancer with no metastasis. Ecancermedicalscience 2023;17:1541.
How to Cite

Bobbo, K. A., Babuga, A. U., Rayyanu, Z. S., Adamu, A., & Bojude, D. A. (2025). SEX DISPARITY IN CANCER OCCURRENCE AND TREATMENT AMONG CANCER PATIENTS: A 2-YEAR RETROSPECTIVE STUDY OF THE ONCOLOGY UNIT, FEDERAL TEACHING HOSPITAL, GOMBE. Nigerian Journal of Oncology, 1(2), 266-279. https://doi.org/10.67579/njo.2025.zg6ha74d

K. A. Bobbo, A. U. Babuga, Z. S. Rayyanu, A. Adamu, and D. A. Bojude, "SEX DISPARITY IN CANCER OCCURRENCE AND TREATMENT AMONG CANCER PATIENTS: A 2-YEAR RETROSPECTIVE STUDY OF THE ONCOLOGY UNIT, FEDERAL TEACHING HOSPITAL, GOMBE," Nigerian Journal of Oncology, vol. 1, no. 2, pp. 266-279, July 2025. doi: 10.67579/njo.2025.zg6ha74d

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