Title: Sarcoma’s and Limb Amputation a Perverse human enemy- The Ibadan experience

Introduction: Sarcomas are rare malignant tumors originating from mesenchymal tissues. Despite advances in limb-sparing techniques, amputation remains a vital option for patients with extensive or non-salvageable limb sarcomas. Objective: This study investigates the demographics, surgical management, and outcomes of patients who underwent limb amputations due to sarcomas in a tertiary Nigerian hospital over a five-year period. Materials and Methods: A retrospective cohort study was conducted at the University College Hospital, Ibadan, involving 39 patients aged 16 years and above who underwent amputations for non-salvageable limb sarcomas between 2018 and 2023. Data on demographics, anaesthesia, blood loss, transfusion, surgical outcomes, and diagnosis were analyzed using descriptive and inferential statistics. Results: The mean age was 36.0±18.02 years, with a male predominance (66.7%). Lower limbs were more frequently affected (64.1%), and soft tissue sarcoma and osteosarcoma were the most common diagnoses. Most surgeries were conducted under spinal anaesthesia (69.3%). ICU admission was rare (2.6%), and the mortality rate was high (48.7%). No statistically significant association was found between mortality and age, sex, or limb involved (p > 0.05). Conclusion: Amputation remains a necessary intervention for advanced sarcomas, particularly in resource-limited settings. The high mortality underscores the need for early detection, multidisciplinary management, and improved access to comprehensive oncologic care.